2016年10月-12月最新进展

发布时间:2017/1/16  浏览数:940次

1、evocatal GmbH 更名为 evoxx

2016年10月:德国海姆的一家生物催化公司evocatal更名为evoxx技术。这次更名是在evocatal和碳水化合物专家aevotis完成合并之后(似乎他们对首字母大写并不是特别感冒)。


2、Codexis完成了对默克的CodeEvolver®技术交付

2016年10月5日:Codexis宣布完成专有CodeEvolver®蛋白质工程平台技术向默克转移的第二个也是最后一个阶段,签署了一份排他性的许可协议。Codexis在2016年第四季度将会收到默克的800万美元的里程碑支付。

 

3、Zymergen融资1.3亿美元

2016年10月11日,合成生物和通路工程科技公司Zymergen日前宣布获得1.3亿美元由软银牵头的B轮融资。该公司从2013年成立至今已经完成了超过2亿美元的增长。

 

4、诺维信推出首个生物泡沫控制剂

2016年11月8号,世界领先的工业酶公司诺维信宣布推出一种名为FermaxTM新的蛋白酶产品,这种蛋白酶能够减少发酵过程中泡沫的产生,如从甘蔗乙醇的发酵过程。更多此蛋白酶的信息见下面的酶介绍。

 

5、Codexis宣布与Tate & Lyle签订酶供应协议

2016年12月6日,Codexis宣布与Tate & Lyle签订一份排他性协议,作为Tate & Lyle的食品原料生产中使用专有酶的全球材料和解决方案的提供者。

会议预告

1)2017年1月9日-10日,生物催化与生物化学:生物催化遇上合成生物学,美国 圣地亚哥;

http://www.chi-peptalk.com/biocatalysts-conference/

 

2)2017年3月6日-8日,有机过程的研究和开发,帕萨迪纳,美国;

https://scientificupdate.co.uk/index.php/conferences/conferences-and-workshops/details/297-Organic-Process-Research-and-Development-Europe.html 

最新发表文献摘选:

1)Fusion of agarase and neoagarobiose hydrolase for mono-sugar production from agar. Alkotaini B, Han NS, Kim BS. Appl Microbiol Biotechnol. 2016 Nov 25.

https://www.ncbi.nlm.nih.gov/pubmed/27888333

 

2)Chemoenzymatic Synthesis of trans-β-Aryl-δ-hydroxy-γ-lactones and Enzymatic Kinetic Resolution of Their Racemic Mixtures. Skrobiszewski A, Gladkowski W, Maciejewska G, Wawrzeńczyk C. Molecules. 2016 Nov 23;21(11). pii: E1552.

https://www.ncbi.nlm.nih.gov/pubmed/27886108

 

3)Sequential Enzymatic Conversion of α-Angelica Lactone to γ-Valerolactone through Hydride-Independent C=C Bond Isomerization. Turrini NG, Eger E, Reiter TC, Faber K, Hall M. ChemSusChem. 2016 Nov 25. doi:10.1002/cssc.201601363.

https://www.ncbi.nlm.nih.gov/pubmed/27885835

 

4)Investigation of Structural Dynamics of Enzymes and Protonation States of Substrates Using Computational Tools. Chang CA, Huang YM, Mueller LJ, You W. Catalysts. 2016 Jun;6(6). pii: 82. https://www.ncbi.nlm.nih.gov/pubmed/27885336

 

5)Directed evolution of cytochrome c for carbon-silicon bond formation: Bringing silicon to life. Kan SB, Lewis RD, Chen K, Arnold FH. Science. 2016 Nov 25;354(6315):1048-1051.

https://www.ncbi.nlm.nih.gov/pubmed/27885032

 

6)The Oxidosqualene Cyclase from the Oomycete Saprolegnia parasitica Synthesizes Lanosterol as a Single Product. Dahlin P, Srivastava V, Bulone V, McKee LS. Front Microbiol. 2016 Nov 9;7:1802.

https://www.ncbi.nlm.nih.gov/pubmed/27881978

 

7)Membrane bioreactors for pharmaceutical applications: optically pure

enantiomers production. Piacentini E, Mazzei R, Giorno L. Curr Pharm Des. 2016 Nov 23.https://www.ncbi.nlm.nih.gov/pubmed/27881063

 

8)Stimulation of Laccase Biocatalysis in Ionic Liquids: A Review on Recent Progress. 

https://www.ncbi.nlm.nih.gov/pubmed/27875965

 

9)Laccase catalysis for the synthesis of bioactive compounds. Kudanga T, Nemadziva B, Le Roes-Hill M. Appl Microbiol Biotechnol. 2016 Nov 21.Review.

https://www.ncbi.nlm.nih.gov/pubmed/27872999

 

10)Protein-based inverse opals: A novel support for enzyme immobilization. >Jiang Y, Sun W, Wang Y, Wang L, Zhou L, Gao J, He Y, Ma L, Zhang X. Enzyme Microb Technol. 2017 Jan;96:42-46. doi: 10.1016/j.enzmictec.2016.08.021.

https://www.ncbi.nlm.nih.gov/pubmed/27871384

 

11)Aroma Release in Wine Using Co-Immobilized Enzyme Aggregates. 2016 Nov 8;21(11). pii: E1485.https://www.ncbi.nlm.nih.gov/pubmed/27834828

 

12)Identification and characterization of a thermostable and cobalt-dependent amidase from Burkholderia phytofirmans ZJB-15079 for efficient synthesis of (R)-3,3,3-trifluoro-2-hydroxy-2-methylpropionic acid. Wu ZM, Zheng RC, Tang XL, Zheng YG. Appl Microbiol Biotechnol. 2016 Nov 10.

https://www.ncbi.nlm.nih.gov/pubmed/27832306

 

13)Structure and function of an ancestral-type β-decarboxylating dehydrogenase from Thermococcus kodakarensis. Shimizu T, Yin L, Yoshida A, Yokooji Y, Hachisuka SI, Sato T, Tomita T, Nishida H, Atomi H, Kuzuyama T, Nishiyama M. Biochem J. 2016 Nov 9. pii: BCJ20160699.

https://www.ncbi.nlm.nih.gov/pubmed/27831491

 

14)Engineering Styrene Monooxygenase for Biocatalysis: Reductase-Epoxidase Fusion Proteins. Heine T, Tucker K, Okonkwo N, Assefa B, Conrad C, Scholtissek A, Schlomann M, Gassner G, Tischler D. Appl Biochem Biotechnol. 2016 Nov 9.

https://www.ncbi.nlm.nih.gov/pubmed/27830466

 

15)High adaptability of the omega loop underlies the substrate-spectrum-extension

evolution of a class A β-lactamase, PenL. Yi H, Choi JM, Hwang J, Prati F, Cao TP, Lee SH, Kim HS. Sci Rep. 2016 Nov 9;6:36527. doi: 10.1038/srep36527.

https://www.ncbi.nlm.nih.gov/pubmed/27827433

 

16)Crystal structure of fuculose aldolase from the Antarctic psychrophilic yeast Glaciozyma antarctica PI12. Jaafar NR, Littler D, Beddoe T, Rossjohn J, Illias RM, Mahadi NM, Mackeen MM, Murad AM, Abu Bakar FD. Acta Crystallogr F Struct Biol Commun. 2016 Nov 1;72(Pt11):831-839. https://www.ncbi.nlm.nih.gov/pubmed/27827354

 

17)Improving the catalytic efficiency of Bacillus pumilus CotA-laccase by site-directed mutagenesis. Chen Y, Luo Q, Zhou W, Xie Z, Cai YJ, Liao XR, Guan ZB. Appl Microbiol Biotechnol. 2016 Nov 8.https://www.ncbi.nlm.nih.gov/pubmed/27826721

 

18)Enhancement of catalytic, reusability, and long-term stability features of Trametes versicolor IBL-04 laccase immobilized on different polymers. Asgher M, Noreen S, Bilal M. Int J Biol Macromol. 2016 Nov 5;95:54-62. doi: 10.1016/j.ijbiomac.2016.11.012.

https://www.ncbi.nlm.nih.gov/pubmed/27825994

 

19)Trypsin-catalyzed multicomponent reaction: A novel and efficient one-pot synthesis of thiazole-2-imine derivatives. Zhou J, Huang X, Zhang Z, Song P, Li Y. J Biotechnol. 2016 Nov 5;241:14-21. doi:

10.1016/j.jbiotec.2016.11.004.

https://www.ncbi.nlm.nih.gov/pubmed/27825826

 

20)Solvent effect on hydrogen bonded Tyr…Asp…Arg triads: Enzymatic catalyzed model system. Yan S, Yao L, Kang B, Lee JY. Comput Biol Chem. 2016 Dec;65:140-147. doi: 10.1016/j.compbiolchem.2016.10.013.

https://www.ncbi.nlm.nih.gov/pubmed/27825065

 

21)Evolution of Ubiquinone Biosynthesis: Multiple Proteobacterial Enzymes with Various Regioselectivities To Catalyze Three Contiguous Aromatic Biocatalysis , Hydroxylation Reactions. Pelosi L, Ducluzeau AL, Loiseau L, Barras F, Schneider D, Junier I, Pierrel F. mSystems. 2016 Aug 30;1(4). pii: e00091-16.

https://www.ncbi.nlm.nih.gov/pubmed/27822549

 

22)Identification of a new plasmid-encoded cytochrome P450 CYP107DY1 from Bacillus megaterium with a catalytic activity towards mevastatin. Milhim M, Putkaradze N, Abdulmughni A, Kern F, Hartz P, Bernhardt R. J Biotechnol. 2016 Dec 20;240:68-75. doi: 10.1016/j.jbiotec.2016.11.002.

https://www.ncbi.nlm.nih.gov/pubmed/27816653

 

23)Rotating packed bed reactor for enzymatic synthesis of biodiesel. Xu J, Liu C, Wang M, Shao L, Deng L, Nie K, Wang F. Bioresour Technol. 2016 Oct 18. pii: S0960-8524(16)31451-1. doi: 10.1016/j.biortech.2016.10.045.

 https://www.ncbi.nlm.nih.gov/pubmed/27816349


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